Evolution of the Molecular Biology of Brain Tumors and the Therapeutic Implications

Evolution of the Molecular Biology of Brain Tumors and the Therapeutic Implications
InTeOpP | 2013 | ISBN: 535109891 9789535109891 | 648 pages | PDF | 21 MB

In this book a review of the latest information on these topics along with a variety of new therapeutic treatment strategies with an emphasis on molecular targeted therapies is provided. This new information will lead to efficacious treatment strategies for these tumors which remain a challenge.

Contents
Preface
Section 1 Angiogenesis and Tumor Invasion
1 Brain Tumor Invasion and Angiogenesis
2 Gliomas Biology: Angiogenesis and Invasion
3 Hypoxia, Angiogenesis and Mechanisms for Invasion of Malignant Gliomas
4 Brain Tumor-Induced Angiogenesis: Approaches and Bioassays
Section 2 Immunotherapy
5 IGF-I Antisense and Triple-Helix Gene Therapy of Glioblastoma
6 Using REMBRANDT to Paint in the Details of Glioma Biology: Applications for Future Immunotherapy
Section 3 Molecular Biology of Brain Tumors and Associated Therapeutic Implications
7 From Gliomagenesis to Multimodal Therapeutic Approaches into High-Grade Glioma Treatment
8 Dipeptidyl Peptidase-IV and Related Proteases in Brain Tumors
9 Apoptotic Events in Glioma Activate Metalloproteinases and Enhance Invasiveness
10 The Distribution and Significance of IDH Mutations in Gliomas
11 Deregulation of Cell Polarity Proteins in Gliomagenesis
12Aquaporin. Midkine and Glioblastoma
13 Porphyrin Synthesis from 5-Aminolevulinic Acid in Patients with Glioma
14 Mechanisms of Aggressiveness in Glioblastoma: Prognostic and Potential Therapeutic Insights
Section 4 Novel Anticancer Agents
15 A Rational for Novel Anti-NeuroOncology Drugs
16 DNA-PK is a Potential Molecular Therapeutic Target for Glioblastoma
Section 5 MicroRNAs
17 Evolvement of microRNAs as Therapeutic Targets for Malignant Gliomas
18 MicroRNAs Regulated Brain Tumor Cell Phenotype and Their Therapeutic Potential
Section 6 Pediatric Brain Tumors
19 Carbonic Anhydrase IX in Adult and Pediatric Brain Tumors
20 New Molecular Targets and Treatments for Pediatric Brain Tumors
Section 7 Radioresistance of Brain Tumors
21 In silico Analysis of Transcription Factors Associated to Differentially Expressed Genes in Irradiated Glioblastoma Cell Lines
Section 8 Stem Cells
22 Brain Tumor Sternness
23 Nestin: Neural Stem/Progenitor Cell Marker in Brain Tumors

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