Congenital Endocrinopathies: New Insights into Endocrine Diseases and Diabetes
Renata Lorini, Mohamad Maghnie, Giuseppe D'Annunzio, Sandro Loche, Martin O. Savage,
2007 | pages: 165 | ISBN: 3805583478 | PDF | 3,9 mb
This volume reports the proceedings of an outstanding symposium, held in Genoa in January 2007, organised by Professor Renata Lorini and Professor Mohamad Maghnie, on the very imaginative subject of congenital endocrino-pathies. This subject is broad by definition and the resulting volume is conse-quently interesting and informative and directly relevant to the care of the patient.
The volume contains reviews of normal and abnormal hypothalamic-pituitary development affecting growth hormone (GH) secretion and defects of the GH-IGF-I axis influencing GH and IGF-I action. Abnormalities of the pituitary-gonadal axis affecting normal puberty are covered together with defects of steroidogenesis involving both adrenal and gonadal development. The effect of glucocorticoid hormone programming in early life and defects of G proteins and their receptors are also described. Key chapters are included on neonatal diabetes, congenital insulin resistance syndromes and the pathogenesis and management of persisting hyperinsulism of infancy. Finally, the application of stem cell research from animal studies to human diagnosis and therapy has been reviewed.
Overall this is an excellent volume. It provides information directly useful to the clinician and stimulates thought and future research opportunities with cutting-edge scientific results in the broad and very important field of congeni-tal endocrinopathies.
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